MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 16S rRNA region and is investigated as an exercise-mimetic metabolic signal. It is studied for its role in activating AMPK pathways, modulating insulin sensitivity, and regulating metabolic homeostasis. Principal research areas include mitochondrial retrograde signaling, metabolic regulation, and exercise physiology models. Supplied as a lyophilized research material for laboratory research applications.